Dados do Trabalho
Aseptic conjunctivitis secondary to risperidone: case report
Apresentação do caso
This is a report of 6 and a half year old child, with a diagnosis of Autistic Spectrum Disorder (ASD) support level 2 and ADHD (Attention Deficit Hyperactivity Disorder) as comorbidity. Pharmacological therapy with risperidone was initiated, with a gradual increase in dose up to 1.25 mL/day, divided into 2 doses, with significant improvement in aggressiveness, agitation, and impulsiveness, as well as evident gains in verbal communication. About 90 days after starting the drug, the mother reported increased appetite, abundant hyaline nasal discharge, and the presence of thick, yellowish eye discharge and red-eye syndrome. In ophthalmologic evaluation, the patient was refractory to the use of antiallergic medication, antibiotics, and lubricants. Due to the persistence of signs and symptoms, a gradual reduction of risperidone was chosen; however, the resolution of ocular complaints was only after the total suspension of the drug. Aripiprazole was subsequently started.
Risperidone is an atypical antipsychotic that has a high affinity for serotonin and dopamine receptors. Among the many situations in which this drug can be administered, it includes the treatment of irritability and aggressiveness associated with ASD. Although safe in the pediatric age group, the drug is not free of side effects. In the case described, the rare manifestation observed was aseptic conjunctivitis, and discontinuation was chosen due to refractory ocular hypersecretion.
It is necessary that individuals undergoing pharmacological therapy with antipsychotics have continuous and longitudinal monitoring. Although the drug chosen is safe for use in pediatric patients, its use is not free of negative and unusual side effects, such as aseptic conjunctivitis. Knowing the indications and complications related to risperidone, is important for the safety and clinical management of cases.
Referências (se houver)
risperidone, conjunctivitis, ASD
Fonte de Fomento (se houver)
Declaração de conflito de interesses de TODOS os autores
Eu, Juliana dos Santos Cristovão, declaro não possuir conflitos de interesse sobre o trabalho em questão.
Eu, Valkiria Kohlrausch Vidal Araujo, declaro não possuir conflitos de interesse sobre o trabalho em questão.
Eu, Raphael Rocha Gomes Urbano, declaro não possuir conflitos de interesse sobre o trabalho em questão.
Eu, Ada Maria Farias Sousa Borges, declaro não possuir conflitos de interesse sobre o trabalho em questão.
UNESP - São Paulo - Brasil, UNICEPLAC - Distrito Federal - Brasil
Juliana Dos Santos Cristovão , Valkiria Kohlrausch Vidal Araujo, Raphael Rocha Gomes Urbano, Ada Maria Farias Sousa Borges